Three‐Component Aminoarylation of Electron‐Rich Alkenes by Merging Photoredox with Nickel Catalysis

A three-component 1,2-aminoarylation of vinyl ethers, enamides, ene-carbamates and thioethers by synergistic photoredox nickel catalysis is reported. 2,2,2-Trifluoroethoxy carbonyl protected α-amino-oxy acids are used as amidyl radical precursors. anti-Markovnikov addition the to alkene Ni-mediated radical/transition metal cross over lead corresponding product. The cascade, which can be conducted under practical mild conditions, features high functional group tolerance broad substrate scope. Stereoselective achieved using a L-(+)-lactic acid derived ether substrate, offering novel route for preparation enantiopure α-arylated β-amino alcohols. In addition, 1,2-aminoacylation ethers an acyl succinimide electrophile coupling.